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Cross-talk between GPER and growth factor signaling

Rosamaria Lappano1, Paola De Marco, Ernestina Marianna De Francesco

  • 1Dipartimento Farmaco-Biologico, Università della Calabria, via P. Bucci, 87036 Rende, Italy.

The Journal of Steroid Biochemistry and Molecular Biology
|April 2, 2013
PubMed

Insights

This review explores the cross-talk between G protein-coupled estrogen receptor 1 (GPER) and growth factor receptors like EGFR and IGF-IR. Understanding these interactions is crucial for cancer therapy and treatment resistance.

Area of Science:

  • Cellular Biology
  • Molecular Oncology
  • Endocrinology

Background:

  • G protein-coupled receptors (GPCRs) and growth factor receptors are key mediators of cellular responses to external signals.
  • These receptors form complex signaling networks influencing normal and cancerous cell behavior.
  • GPCRs can transactivate growth factor receptors, impacting pathways like gene expression and cell proliferation.

Purpose of the Study:

  • To review recent findings on the cross-talk between G protein-coupled estrogen receptor 1 (GPER) and growth factor receptors.
  • To discuss the biological implications of this interaction, particularly in the context of cancer.
  • To highlight the functional interplay between GPER, EGFR, and IGF-IR.

Main Methods:

  • Literature review of recent scientific findings.
  • Analysis of signaling pathways involving GPCRs and growth factor receptors.
  • Discussion of functional interactions and their biological consequences.

Main Results:

  • GPCRs and growth factor receptors generate multifaceted signaling networks.
  • GPCRs can transactivate growth factor receptors, such as EGFR.
  • Functional interactions between growth factor receptors and estrogens are implicated in tumor growth and endocrine therapy resistance.

Conclusions:

  • The cross-talk between GPER and growth factor receptors (EGFR, IGF-IR) has significant biological implications in cancer.
  • Understanding these interactions is vital for developing targeted cancer therapies.
  • Further research into these signaling networks may reveal new therapeutic strategies for endocrine-resistant cancers.
Keywords:
CancerEGFREstrogenGPR30/GPERGrowth factor signalingIGF-IR

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