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Updated: May 12, 2026
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Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
Published on: June 15, 2017
Cross-talk between GPER and growth factor signaling
Rosamaria Lappano1, Paola De Marco, Ernestina Marianna De Francesco
1Dipartimento Farmaco-Biologico, Università della Calabria, via P. Bucci, 87036 Rende, Italy.
Summary
This review explores the cross-talk between G protein-coupled estrogen receptor 1 (GPER) and growth factor receptors like EGFR and IGF-IR. Understanding these interactions is crucial for cancer therapy and treatment resistance.
Area of Science:
- Cellular Biology
- Molecular Oncology
- Endocrinology
Background:
- G protein-coupled receptors (GPCRs) and growth factor receptors are key mediators of cellular responses to external signals.
- These receptors form complex signaling networks influencing normal and cancerous cell behavior.
- GPCRs can transactivate growth factor receptors, impacting pathways like gene expression and cell proliferation.
Purpose of the Study:
- To review recent findings on the cross-talk between G protein-coupled estrogen receptor 1 (GPER) and growth factor receptors.
- To discuss the biological implications of this interaction, particularly in the context of cancer.
- To highlight the functional interplay between GPER, EGFR, and IGF-IR.
Main Methods:
- Literature review of recent scientific findings.
- Analysis of signaling pathways involving GPCRs and growth factor receptors.
- Discussion of functional interactions and their biological consequences.
Main Results:
- GPCRs and growth factor receptors generate multifaceted signaling networks.
- GPCRs can transactivate growth factor receptors, such as EGFR.
- Functional interactions between growth factor receptors and estrogens are implicated in tumor growth and endocrine therapy resistance.
Conclusions:
- The cross-talk between GPER and growth factor receptors (EGFR, IGF-IR) has significant biological implications in cancer.
- Understanding these interactions is vital for developing targeted cancer therapies.
- Further research into these signaling networks may reveal new therapeutic strategies for endocrine-resistant cancers.
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