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Related Experiment Video

Updated: May 12, 2026

Natural Killer (NK) and CAR-NK Cell Expansion Method using Membrane Bound-IL-21-Modified B Cell Line

Natural Killer (NK) and CAR-NK Cell Expansion Method using Membrane Bound-IL-21-Modified B Cell Line

Published on: February 8, 2022

Chicken NK cell receptors.

Christian Straub¹, Marie-Luise Neulen, Beatrice Sperling

¹Institute for Animal Physiology, Department of Veterinary Sciences, University of Munich, Germany.

Developmental and Comparative Immunology

|April 2, 2013

Summary

Natural killer (NK) cells are crucial innate immune cells. This review highlights recent advancements in understanding diverse NK cell receptor families, focusing on novel chicken NK cell receptor candidates.

Keywords:

CHIR Chicken IEL ITAM ITIM ITSM KIR LRC Leukocyte receptor complex NCR NK cell receptor NKC SLAM TILR chicken Ig-like receptor immunoreceptor tyrosine-based activation motif immunoreceptor tyrosine-based inhibitory motif immunoreceptor tyrosine-based switch motif intestinal intraepithelial lymphocytes killer cell immunoglobulin-like receptors leukocyte receptor complex natural cytotoxicity receptors natural killer gene complex signaling lymphocytic activation molecule turkey Ig-like receptor

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A BW Reporter System for Studying Receptor-Ligand Interactions

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Published on: January 7, 2019

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Last Updated: May 12, 2026

Natural Killer (NK) and CAR-NK Cell Expansion Method using Membrane Bound-IL-21-Modified B Cell Line

Natural Killer (NK) and CAR-NK Cell Expansion Method using Membrane Bound-IL-21-Modified B Cell Line

Published on: February 8, 2022

A BW Reporter System for Studying Receptor-Ligand Interactions

A BW Reporter System for Studying Receptor-Ligand Interactions

Published on: January 7, 2019

Area of Science:

Immunology
Cell Biology
Genomics

Background:

Natural killer (NK) cells are innate immune cells that eliminate virally infected or transformed cells.
Mammalian NK cells utilize diverse activating and inhibitory receptors for target cell recognition, differing from lymphocytes with antigen receptors.
Chicken NK cells are functionally and morphologically defined, but their specific receptors remain largely uncharacterized.

Purpose of the Study:

To review recent progress on diverse NK cell receptor families.
To emphasize novel receptor families identified in the chicken genome with potential roles in chicken NK cell function.

Main Methods:

Review of existing literature on NK cell receptors in mammals and chickens.
Analysis of the chicken genome for identification of novel gene families potentially encoding NK cell receptors.
Functional and morphological characterization of chicken NK cells (implied by background).

Main Results:

Several mammalian NK cell receptor families involved in immune regulation have been identified.
Novel gene families with potential as chicken NK cell receptors have been identified in the chicken genome.
Low frequencies of chicken NK cells in blood/spleen have historically hindered their characterization.

Conclusions:

Understanding NK cell receptors is critical for innate immunity research.
The identified novel chicken gene families represent promising candidates for chicken NK cell receptors.
Further research is needed to confirm the function of these novel receptors in chicken NK cell-mediated immunity.