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Regulation of macrophage and dendritic cell function by pathogens and through immunomodulation in the avian mucosa

Eveline D de Geus1, Lonneke Vervelde

  • 1Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands. e.d.degeus@uu.nl

Developmental and Comparative Immunology
|April 2, 2013
PubMed

Insights

This review explores macrophage (MPh) and dendritic cell (DC) functions in chickens, focusing on their roles in recognizing and responding to pathogens. It highlights strategies like nutraceuticals and vaccination to enhance disease resistance.

Area of Science:

  • Immunology
  • Cell Biology
  • Veterinary Science

Background:

  • Macrophages (MPh) and dendritic cells (DC) are key components of the mononuclear phagocyte system.
  • Distinguishing MPh from DC in chickens is challenging due to a lack of specific markers.
  • The distinction between MPh and DC is also debated in humans and mice, despite available markers.

Purpose of the Study:

  • To review the current understanding of MPh and DC function in chickens.
  • To examine MPh and DC receptors involved in pathogen recognition.
  • To discuss MPh and DC responses to respiratory and intestinal pathogens in chickens.

Main Methods:

  • Literature review of MPh and DC function and pathogen responses in chickens.
  • Analysis of MPh and DC receptors involved in immune recognition.
  • Exploration of strategies to modulate MPh and DC activity.

Main Results:

  • Mucosal MPh and DC are strategically positioned for antigen uptake and rapid pathogen response.
  • MPh and DC play crucial roles in recognizing and responding to various pathogens.
  • Specific receptors mediate pathogen recognition by MPh and DC.

Conclusions:

  • Understanding MPh and DC responses is vital for combating avian diseases.
  • Modulating MPh and DC activity offers potential for enhancing disease resistance.
  • Nutraceuticals and vaccination are promising approaches to enhance MPh and DC-mediated immunity.
Keywords:
(Draining) lymph nodesAIVAPCAgBALTBMC-type lectin receptorsCGCLRDCDC-SIGNDC-specific intercellular adhesion molecule-3-grabbing non-integrinDendritic cellsGALTHAHPAIIAVIBDVIBVImmunomodulationInfectionLGP2LPAILPSMDA5MGLMMRMPhMacrophagesMucosalNANALTNDVPRRRIG-IRTTLRantigenantigen-presenting cellsavian influenza virusbone marrowbronchus-associated lymphoid tissuecLLchicken galectinchicken lung lectindLNdendritic cellsgut-associated lymphoid tissuehaemagglutininhighly-pathogenic avian influenzainfectious bronchitis virusinfectious bursal diease virusinfluenza A viruslaboratory of genetics and physiology 2lipopolysaccharidelow pathogenic influenzamacrophage galactose binding lectinmacrophage mannose receptormacrophagesmelanoma differentiation-associated protein 5nasal associated lymphoid tissueneuraminidasenewcastle disease viruspattern recognition receptorsrespiratory tractretinoic acid-inducible gene Itoll-like receptors

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