Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Metachronous colorectal carcinoma.

S Bülow1, L B Svendsen, A Mellemgaard

  • 1Department of Surgical Gastroenterology, Hvidovre Hospital, Denmark.

The British Journal of Surgery
|May 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endoscopic indicators in patients with familial adenomatous polyposis undergoing duodenal resections - a nationwide Danish cohort study with long-term follow-up.

Familial cancer·2024
Same author

Effects of high-intensity exercise training on physical fitness, quality of life and treatment outcomes after oesophagectomy for cancer of the gastro-oesophageal junction: PRESET pilot study.

BJS open·2020
Same author

ALK immunohistochemistry positive, FISH negative NSCLC is infrequent, but associated with impaired survival following treatment with crizotinib.

Lung cancer (Amsterdam, Netherlands)·2019
Same author

Expert consensus on a train-the-trainer curriculum for robotic colorectal surgery.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2019
Same author

Safety and feasibility of preoperative exercise training during neoadjuvant treatment before surgery for adenocarcinoma of the gastro-oesophageal junction.

BJS open·2019
Same author

Ghrelin secretion in humans - a role for the vagus nerve?

Neurogastroenterology and motility·2018

Young patients under 40 with colorectal carcinoma face a significant risk of developing a second cancer. Lifelong surveillance, including Hemoccult tests and colonoscopies, is recommended after initial treatment.

Area of Science:

  • Oncology
  • Gastroenterology
  • Clinical Medicine

Background:

  • Colorectal carcinoma (CRC) in patients under 40 years old is relatively rare but presents unique challenges.
  • Understanding the long-term risk of metachronous CRC after initial curative-intent surgery is crucial for this demographic.

Purpose of the Study:

  • To investigate the incidence and cumulative risk of metachronous colorectal carcinoma in young patients (<40 years) after curative resection.
  • To evaluate the long-term survival outcomes for patients who develop a metachronous CRC.
  • To propose an optimal follow-up strategy for this high-risk patient group.

Main Methods:

  • Retrospective analysis of 903 Danish patients diagnosed with colorectal carcinoma between 1943 and 1967, all under 40 years of age.

Related Experiment Videos

  • Long-term follow-up (up to 41 years) to identify metachronous colorectal carcinoma development.
  • Survival analysis for patients who underwent surgery for metachronous CRC.

    • Main Results:

    • Among 501 patients operated on for cure, 44 (9%) developed a metachronous colorectal carcinoma.
    • The cumulative risk of developing a metachronous CRC reached 30% over 41 years of observation, with occurrence evenly distributed.
    • The 20-year cumulative survival rate after surgery for metachronous CRC was 41%.

    Conclusions:

    • Patients under 40 treated for colorectal carcinoma have a substantial lifetime risk of developing a second primary CRC.
    • A lifelong follow-up program is warranted for this population.
    • Recommended surveillance includes annual Hemoccult tests and colonoscopies every 3 years.