Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phase 1 evaluation of patients with newly diagnosed glioblastoma treated with radiation, nivolumab, and IDO1 enzyme inhibitor BMS-986205.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

A phase I/II study of intrathecal trastuzumab in human epidermal growth factor receptor 2-positive (HER2-positive) cancer with leptomeningeal metastases: Safety, efficacy, and cerebrospinal fluid pharmacokinetics.

Neuro-oncology·2022
Same author

Neural stem cell delivery of an oncolytic adenovirus in newly diagnosed malignant glioma: a first-in-human, phase 1, dose-escalation trial.

The Lancet. Oncology·2021
Same author

Long-term glioblastoma survival following recovery from cytomegalovirus colitis: A case report.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2019
Same author

The Role of Imaging in the Management of Cystic Formations of the Mobile Spine (CYFMOS).

Current pain and headache reports·2018
Same author

Neuroimaging of spine tumors.

Handbook of clinical neurology·2016

Related Experiment Video

Updated: May 12, 2026

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation
09:43

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation

Published on: January 14, 2014

Anaplastic astrocytoma.

Sean A Grimm1, Thomas J Pfiffner

  • 1Department of Neurology, University of Minnesota School of Medicine, 420 Delaware Street SE, MMC 295, Minneapolis, MN, 55455, USA, sgrimm@umn.edu.

Current Treatment Options in Neurology
|April 2, 2013
PubMed
Summary
This summary is machine-generated.

Standard anaplastic astrocytoma treatment involves surgery and radiation, with chemotherapy like temozolomide (TMZ) considered. Current practices extrapolate from glioblastoma data, pending further research on optimal chemoradiotherapy for AA.

More Related Videos

Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice
10:13

Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice

Published on: August 12, 2014

Translational Orthotopic Models of Glioblastoma Multiforme
07:37

Translational Orthotopic Models of Glioblastoma Multiforme

Published on: February 17, 2023

Related Experiment Videos

Last Updated: May 12, 2026

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation
09:43

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation

Published on: January 14, 2014

Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice
10:13

Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice

Published on: August 12, 2014

Translational Orthotopic Models of Glioblastoma Multiforme
07:37

Translational Orthotopic Models of Glioblastoma Multiforme

Published on: February 17, 2023

Area of Science:

  • Neuro-oncology
  • Clinical Practice Guidelines
  • Cancer Treatment

Background:

  • Anaplastic astrocytoma (AA) management in good performance patients typically includes surgery and radiotherapy (RT).
  • Concurrent and adjuvant temozolomide (TMZ) use is common, but lacks prospective data specific to AA.
  • Current treatment protocols often extrapolate from glioblastoma (GB) studies, a practice that remains controversial.

Purpose of the Study:

  • To outline current treatment standards for anaplastic astrocytoma.
  • To address the extrapolation of glioblastoma data to anaplastic astrocytoma treatment.
  • To highlight ongoing research and supportive care considerations.

Main Methods:

  • Review of standard treatment protocols for anaplastic astrocytoma.
  • Discussion of evidence extrapolation from glioblastoma studies.
  • Consideration of supportive care measures and salvage therapies.

Main Results:

  • Maximal safe surgical resection followed by RT is standard.
  • Chemoradiotherapy with TMZ is often used, based on extrapolated data.
  • Supportive care includes corticosteroid tapering, levetiracetam for seizures, and LMWH for VTE.
  • At recurrence, cytotoxic chemotherapy (TMZ or lomustine) or bevacizumab for symptom management are options.

Conclusions:

  • Optimal initial treatment for AA is under investigation, with a phase III trial ongoing.
  • Supportive care is crucial for managing neurologic dysfunction and complications.
  • Enrollment in clinical trials is encouraged due to limited options at recurrence.