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Updated: May 12, 2026

Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication
14:52

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Published on: December 11, 2013

Buflomedil for intermittent claudication.

Tine L M de Backer1, Robert Vander Stichele

  • 1Heart Center, Ghent University Hospital, Ghent, Belgium. tine.debacker@ugent.be

The Cochrane Database of Systematic Reviews
|April 2, 2013
PubMed
Summary
This summary is machine-generated.

Buflomedil offers moderate improvements in walking distance for intermittent claudication (IC) patients, but evidence is limited. Safety concerns and publication bias temper its potential benefits for peripheral vascular disease.

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Area of Science:

  • Vascular Medicine
  • Pharmacology
  • Clinical Trials

Background:

  • Intermittent claudication (IC) is characterized by exercise-induced limb pain due to chronic occlusive arterial disease.
  • Buflomedil is a vasoactive agent used for peripheral vascular disease, but its efficacy for IC requires critical evaluation.
  • This review updates previous Cochrane analyses from 2000, 2007, and 2008.

Purpose of the Study:

  • To critically assess the available scientific evidence regarding the effectiveness of buflomedil in treating intermittent claudication.
  • To synthesize findings from randomized controlled trials (RCTs) evaluating buflomedil's impact on walking distances in IC patients.

Main Methods:

  • Searched specialized databases (Cochrane Peripheral Vascular Diseases Group) up to January 2013.
  • Included double-blinded RCTs comparing oral buflomedil to placebo in patients with IC (Fontaine stage II).
  • Analyzed pain-free walking distance (PFWD) and maximum walking distance (MWD) using standardized exercise tests; assessed trial quality and extracted data.

Main Results:

  • Two RCTs involving 127 participants were included.
  • Buflomedil demonstrated statistically significant, moderate improvements in both PFWD and MWD compared to placebo.
  • Improvements in PFWD were observed in general and diabetic populations, with significant gains in MWD.

Conclusions:

  • Limited high-quality evidence exists for buflomedil's efficacy in intermittent claudication.
  • Positive results from included trials are potentially biased by the exclusion of at least four unpublished studies.
  • Buflomedil's modest benefits must be weighed against safety concerns and its narrow therapeutic index.