Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 12, 2026

Real-Time Dynamic Navigation System for the Precise Quad-Zygomatic Implant Placement in a Patient with a Severely Atrophic Maxilla

Real-Time Dynamic Navigation System for the Precise Quad-Zygomatic Implant Placement in a Patient with a Severely Atrophic Maxilla

Published on: October 18, 2021

Interventions for replacing missing teeth: different times for loading dental implants.

Marco Esposito¹, Maria Gabriella Grusovin, Hassan Maghaireh

¹Cochrane Oral Health Group, School of Dentistry, The University of Manchester, Manchester, UK. espositomarco@hotmail.com.

The Cochrane Database of Systematic Reviews

|April 2, 2013

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Interventions for preventing oral mucositis in people receiving cancer treatment: photobiomodulation.

The Cochrane database of systematic reviews·2024

Same author

Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults.

The Cochrane database of systematic reviews·2024

Same author

Water fluoridation for the prevention of dental caries.

The Cochrane database of systematic reviews·2024

Same author

Adjunctive antimicrobial photodynamic therapy for treating periodontal and peri-implant diseases.

The Cochrane database of systematic reviews·2024

Same author

Topical fluoride as a cause of dental fluorosis in children.

The Cochrane database of systematic reviews·2024

Same author

Orthodontic treatment for prominent lower front teeth (Class III malocclusion) in children.

The Cochrane database of systematic reviews·2024

This study found no significant difference in dental implant success rates between immediate, early, or conventional loading protocols. Further high-quality randomized controlled trials are needed to confirm these findings for implant and prosthesis survival.

Area of Science:

Dental Implantology
Prosthodontics
Biomaterials Science

Background:

Conventional dental implant loading requires 3-8 months for osseointegration, aiming to minimize failure risks.
Accelerated healing periods through early or immediate loading could offer patient benefits if implant success is maintained.
The comparative success rates of immediate, early, and conventional loading protocols require thorough evaluation.

Purpose of the Study:

To compare the clinical outcomes of immediate (within 1 week), early (1 week-2 months), and conventional (after 2 months) loading of osseointegrated dental implants.
To assess the impact of occlusal vs. non-occlusal loading and direct vs. progressive loading on implant success.
To evaluate prosthesis and implant failures, and marginal bone level changes across different loading protocols.

Related Experiment Videos

Last Updated: May 12, 2026

Real-Time Dynamic Navigation System for the Precise Quad-Zygomatic Implant Placement in a Patient with a Severely Atrophic Maxilla

Real-Time Dynamic Navigation System for the Precise Quad-Zygomatic Implant Placement in a Patient with a Severely Atrophic Maxilla

Published on: October 18, 2021

Main Methods:

A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted.
Searches included major electronic databases (Cochrane, CENTRAL, MEDLINE, EMBASE) up to June 2012.
Data extraction and risk of bias assessment were performed independently by at least two authors; fixed-effect models were used for analysis.

Main Results:

Twenty-six RCTs involving 1217 participants and 2120 implants were included; 2.5% mean implant failure rate observed.
No significant difference in prosthesis or implant failure rates between immediate and conventional loading in the first year.
A small, potentially not clinically important, reduction in bone loss favored immediate loading; insufficient evidence for early loading comparisons.

Conclusions:

Currently, there is no convincing clinical evidence demonstrating a significant difference in implant or prosthesis failure, or bone loss, based on loading time.
Further high-quality, well-designed RCTs adhering to CONSORT guidelines are necessary to provide more definitive conclusions.
The findings suggest that current loading protocols may not critically impact short-term implant outcomes, but long-term data and robust trials are needed.