Epidermal growth factor receptor expression in demented and aged human brain
S D Styren1, E J Mufson, G C Styren
1Department of Zoology, Arizona State University, Tempe 85287.
Abstract:
Immunoreactivity to epidermal growth factor receptor (EGFR) was present in the brain vasculature of 13/13 demented elderly patients, but absent in 9/11 non-demented elderly patients. Of the two positive non-demented patients, one had significant Alzheimer's pathology and the other spinal carcinoma. Ultrastructurally, EGFR is localized to the lumenal surface of endothelial cells.
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