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Published on: November 21, 2013
Olanzapine induced neuroleptic malignant syndrome
Bichitra Nanda Patra1, Sudhir K Khandelwal, Mamta Sood
1Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Indian Journal of Pharmacology
|April 2, 2013
Summary
A young man with bipolar disorder developed neuroleptic malignant syndrome (NMS) from olanzapine, an atypical antipsychotic. Prompt treatment with bromocriptine and levodopa led to good recovery, highlighting NMS risks with atypical antipsychotics.
Area of Science:
- Psychiatry
- Pharmacology
- Neurology
Background:
- Bipolar affective disorder (BPAD) is a mood disorder requiring antipsychotic medication.
- Neuroleptic Malignant Syndrome (NMS) is a rare but life-threatening condition associated with antipsychotic use.
- Atypical antipsychotics, like olanzapine, are increasingly used for BPAD, but their association with NMS is less common than typical antipsychotics.
Observation:
- An 18-year-old male diagnosed with bipolar affective disorder (BPAD) was treated with olanzapine (20 mg/day).
- The patient subsequently developed symptoms consistent with Neuroleptic Malignant Syndrome (NMS).
- This case highlights NMS development despite the use of an atypical antipsychotic agent.
Findings:
- The patient was diagnosed with NMS, and olanzapine was immediately discontinued.
- Treatment with bromocriptine and levodopa was initiated promptly.
- The patient showed a good clinical recovery following the intervention.
Implications:
- This case underscores the potential risk of NMS even with atypical antipsychotics like olanzapine.
- Early recognition and withdrawal of the offending agent, coupled with appropriate medical management, are crucial for favorable outcomes in NMS.
- Further vigilance is warranted regarding NMS in patients treated with atypical antipsychotics, considering its potential mortality.
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