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Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
Published on: September 15, 2017
RAGE regulation and signaling in inflammation and beyond
Katrin Kierdorf1, Günter Fritz
1Department of Neuropathology, University of Freiburg, Freiburg, Germany.
Journal of Leukocyte Biology
|April 2, 2013
Summary
Receptor for Advanced Glycation Endproducts (RAGE) links innate and adaptive immunity. This review explores RAGE
Area of Science:
- Immunology
- Cell Biology
- Molecular Biology
Background:
- Receptor for Advanced Glycation Endproducts (RAGE) is crucial in inflammation.
- RAGE acts as a bridge between innate and adaptive immune responses.
- It is an Ig superfamily cell-surface receptor found on leukocytes and endothelium.
Purpose of the Study:
- To review current knowledge on RAGE signaling pathways.
- To discuss RAGE activation mechanisms.
- To explore potential therapeutic interventions targeting RAGE.
Main Methods:
- Literature review of studies on RAGE.
- Analysis of RAGE expression and function in various cell types.
- Examination of RAGE ligand interactions and downstream signaling.
Main Results:
- RAGE promotes leukocyte activation, migration, and maturation.
- It mediates leukocyte adhesion and transmigration on activated endothelium.
- RAGE recognizes structural motifs on diverse ligands, acting as a pattern recognition receptor (PRR).
Conclusions:
- RAGE plays a significant role in inflammatory processes.
- Understanding RAGE signaling offers therapeutic opportunities.
- RAGE represents a potential target for modulating immune responses.
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