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Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...

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Related Experiment Video

Updated: May 12, 2026

Modeling Brain Metastasis Via Tail-Vein Injection of Inflammatory Breast Cancer Cells
05:02

Modeling Brain Metastasis Via Tail-Vein Injection of Inflammatory Breast Cancer Cells

Published on: February 4, 2021

Inflammatory breast carcinoma.

Kelli Y Ha1, Shannon B Glass, Louba Laurie

  • 1Department of Radiology, Baylor University Medical Center at Dallas.

Proceedings (Baylor University. Medical Center)
|April 2, 2013
PubMed
Summary
This summary is machine-generated.

Inflammatory breast carcinoma is a rare, aggressive cancer presenting with skin changes like redness and thickening. Early and accurate diagnosis through imaging is crucial to distinguish it from infections or skin conditions.

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Area of Science:

  • Oncology
  • Radiology
  • Dermatology

Background:

  • Inflammatory breast carcinoma (IBC) is a rare, aggressive subtype of invasive breast cancer.
  • It often presents with clinical signs mimicking infection, such as erythema and edema.
  • Typical age of onset is between the fourth and fifth decades.

Observation:

  • A case of a 49-year-old woman with IBC in the left breast is presented.
  • The characteristic "peau de orange" (orange peel) skin thickening is noted.
  • Imaging modalities include mammography, sonography, and breast magnetic resonance imaging.

Findings:

  • IBC demonstrates specific appearances on mammography, sonography, and MRI.
  • Radiologic findings are crucial for differentiating IBC from mastitis or dermatologic disorders.
  • Accurate imaging characterization is vital for appropriate patient management.

Implications:

  • Misdiagnosis of IBC as infection can lead to delayed treatment and poorer outcomes.
  • Enhanced radiologic evaluation improves diagnostic accuracy for this aggressive breast cancer.
  • Timely and correct diagnosis of IBC is paramount for effective clinical intervention.