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Published on: March 30, 2018
Plasmablastic lymphoma following transplantation.
Michael J Van Vrancken1, Latoya Keglovits, John Krause
1Department of Pathology, Baylor University Medical Center at Dallas.
Proceedings (Baylor University. Medical Center)
|April 2, 2013
Summary
Posttransplant lymphoproliferative disorder (PTLD) can occur after transplantation. This study describes two new cases of plasmablastic lymphoma, a PTLD variant, in lung and pancreas transplant recipients.
Area of Science:
- Oncology
- Immunology
- Transplantation Medicine
Background:
- Posttransplant lymphoproliferative disorder (PTLD) is a significant complication after solid organ and hematopoietic stem cell transplantation.
- Prolonged immunosuppressive therapy is a primary risk factor for PTLD development.
Observation:
- Plasmablastic lymphoma, typically associated with HIV, is an increasingly recognized variant of PTLD in transplant recipients.
- This report details two novel cases of plasmablastic lymphoma occurring after lung and pancreatic transplantation, respectively.
- Clinical presentations of plasmablastic lymphoma in transplant patients can be diverse.
Findings:
- The study summarizes demographic, therapeutic, and immunophenotypic data from previously reported cases of plasmablastic lymphoma in transplant patients.
- This adds to the limited literature on this rare PTLD variant.
Implications:
- Understanding the characteristics of plasmablastic lymphoma in transplant recipients is crucial for timely diagnosis and management.
- Further research into the specific risk factors and optimal treatment strategies for this PTLD variant is warranted.
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