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Use of a Wireless Video-EEG System to Monitor Epileptiform Discharges Following Lateral Fluid-Percussion Induced Traumatic Brain Injury
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Persistent giant U wave inversion with anoxic brain injury.

Matthew N Peters1, Morgan J Katz, Lucius A Howell

  • 1Department of Internal Medicine, Tulane University Health Sciences Center, New Orleans, LA (Peters, Katz, Howell, Moscona, Turnage); and Tulane University Heart and Vascular Institute, New Orleans, LA (Delafontaine).

Proceedings (Baylor University. Medical Center)
|April 2, 2013
PubMed
Summary

Inverted U waves on an electrocardiogram typically signal cardiovascular disease. However, this case shows giant inverted U waves in a patient with a history of brain injury but no heart issues, challenging this association.

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Area of Science:

  • Cardiology
  • Neurology
  • Electrocardiography

Background:

  • Electrocardiographic (ECG) changes are common with acute neurological events.
  • Large, upright U waves can occur following neurological events.
  • Inverted U waves on ECG are usually indicative of cardiovascular disease.

Observation:

  • A 29-year-old male patient with a history of anoxic brain injury was evaluated.
  • The patient had no known pre-existing cardiovascular disease.
  • His electrocardiogram revealed persistent giant inverted U waves.

Findings:

  • The presence of giant inverted U waves in this case is unusual.
  • This finding occurred in the absence of apparent cardiovascular disease.
  • The patient's neurological history (anoxic brain injury) is a key feature.

Implications:

  • This case challenges the established association of inverted U waves solely with cardiovascular pathology.
  • It suggests a potential link between neurological events and inverted U waves.
  • Further research is needed to understand the neurocardiac interplay in ECG abnormalities.