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Updated: May 12, 2026
10:08
Pseudofracture: An Acute Peripheral Tissue Trauma Model
Published on: April 18, 2011
[Relationships between damage-associated molecular patterns and organ injury]
Satoshi Hagiwara1, Takayuki Noguchi
1Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu 879-5593.
Masui. the Japanese Journal of Anesthesiology
|April 3, 2013
Summary
Damage-associated molecular patterns (DAMPs) signal danger during inflammation and organ injury. Targeting DAMPs with therapies shows promise for treating severe systemic inflammation and related conditions.
Area of Science:
- Immunology
- Cell Biology
Context:
- Damage-associated molecular patterns (DAMPs) are intracellular components released during inflammation and organ injury.
- Under normal conditions, DAMPs are retained intracellularly but are secreted in response to systemic or chronic inflammation.
Purpose:
- To explore the role of DAMPs in alerting the immune system to danger.
- To investigate the therapeutic potential of targeting DAMPs for inflammatory conditions.
Summary:
- DAMPs are recognized by pattern recognition receptors (PRRs), such as Toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE).
- DAMP signaling activates intracellular pathways, including NF-kappaB, leading to cytokine production and immune cell activation (macrophages, dendritic cells).
- Therapeutic strategies using antibodies against DAMPs (e.g., anti-HMGB1, anti-histone, anti-RAGE) have shown efficacy in mitigating inflammation and organ injury in preclinical models.
Impact:
- DAMPs represent promising novel therapeutic targets for severe systemic inflammatory diseases like sepsis.
- Anti-DAMP therapies are anticipated to become more prevalent in clinical practice for managing inflammatory disorders.
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