Reversible pH-responsive aggregates based on the self-assembly of functionalized POSS and hyaluronic acid
Lu Lu1, Chaowen Zhang, Lihua Li
1Department of Materials Science and Engineering, Jinan University, Guangzhou 510630, China. tlulu@jnu.edu.cn
Abstract:
We report here the self-assembly of reversible pH intelligent aggregate from natural polysaccharide hyaluronic acid and functionalized polyhedral oligomeric silsesquioxane with tertiary amines and hydroxyls (POSS-AH). Various forms such as micelles, sacs and membranes were self-assembled through different procedures in this organic/inorganic hybrid system. The complex can be manipulated simply by changing pH to produce hydrogen-bond and ionic interaction. Furthermore the aggregates can form at a wide pH range by adjusting the proportion of the two constituents. These pH-responsive composites will offer potential opportunities in many fields, including cell immune barriers, drug and gene delivery systems and chemical sensors.
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