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Updated: May 12, 2026
09:41
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
Managed care aspects of managing multiple sclerosis.
1Pharmacy Department, Monmouth Medical Center, Long Branch, New Jersey, USA. smathis@barnabashealth.org
The American Journal of Managed Care
|April 3, 2013
Summary
Multiple sclerosis (MS) pharmacoeconomic studies show cost-effectiveness improves when focusing on prevented relapses rather than quality-adjusted life-years. Strategies like adherence support and disease management programs optimize therapy effectiveness and patient care.
Area of Science:
- Health Economics
- Neurology
- Pharmacoeconomics
Background:
- Multiple sclerosis (MS) incurs substantial direct and indirect healthcare costs.
- Previous pharmacoeconomic analyses of MS therapies often yielded unfavorable cost-effectiveness ratios based on quality-adjusted life-years.
Purpose of the Study:
- To evaluate the cost-effectiveness of multiple sclerosis therapies.
- To explore alternative endpoints for assessing the economic value of MS treatments.
Main Methods:
- Review of existing pharmacoeconomic studies on multiple sclerosis therapies.
- Analysis of cost-effectiveness based on quality-adjusted life-years versus prevented relapses.
- Consideration of limitations in prior study assumptions and data.
Main Results:
- Cost-effectiveness was generally unfavorable when using quality-adjusted life-years as the primary endpoint.
- Cost-effectiveness results became more favorable when prevented relapses were utilized as the endpoint.
- Limitations including assumptions, projected outcomes, and lack of adverse event data were noted in analyzed studies.
Conclusions:
- Prevented relapses offer a more favorable endpoint for assessing the cost-effectiveness of multiple sclerosis therapies compared to quality-adjusted life-years.
- Managed care professionals and clinicians should promote therapy adherence and implement disease management programs.
- Specialty pharmacies can enhance cost control and patient engagement in managing multiple sclerosis.
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