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Related Experiment Video

Updated: May 12, 2026

A Pulmonary Trunk Banding Model of Pressure Overload Induced Right Ventricular Hypertrophy and Failure
06:47

A Pulmonary Trunk Banding Model of Pressure Overload Induced Right Ventricular Hypertrophy and Failure

Published on: November 29, 2018

High PLTP activity is associated with depressed left ventricular systolic function.

Xueying Chen1, Aijun Sun, Yunzeng Zou

  • 1Institute of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, PR China.

Atherosclerosis
|April 3, 2013
PubMed
Summary

Higher phospholipid transfer protein (PLTP) activity is linked to reduced left ventricular (LV) systolic function. This association is dose-dependent and independent of coronary heart disease, also correlating with unstable coronary heart disease.

Related Experiment Videos

Last Updated: May 12, 2026

A Pulmonary Trunk Banding Model of Pressure Overload Induced Right Ventricular Hypertrophy and Failure
06:47

A Pulmonary Trunk Banding Model of Pressure Overload Induced Right Ventricular Hypertrophy and Failure

Published on: November 29, 2018

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Lipid Metabolism

Background:

  • Phospholipid transfer protein (PLTP) influences lipoprotein metabolism, inflammation, and oxidative stress.
  • Elevated PLTP activity is implicated in atherosclerosis and its risk factors.
  • Existing data on the direct link between PLTP activity and left ventricular (LV) function are limited.

Purpose of the Study:

  • To investigate the relationship between PLTP activity and LV ejection fraction (LVEF) in a Chinese cohort.
  • To determine if PLTP activity is associated with impaired LV systolic function.

Main Methods:

  • Coronary angiography was performed on 732 patients.
  • PLTP activity levels were measured and correlated with clinical parameters, including LVEF.
  • Multivariate analyses were conducted to assess independent associations.

Main Results:

  • PLTP activity showed significant correlations with age, gender, diabetes, triglycerides, HDL-C, apo A, apo B, fibrinogen, and LVEF.
  • Median PLTP activity was significantly higher in patients with reduced LV systolic function (LVEF <50%) compared to those with normal function.
  • A dose-dependent increase in PLTP levels was observed across categories of LV dysfunction (normal, mild, moderate-severe).
  • Higher PLTP activity was also associated with unstable coronary artery disease (AP) compared to stable AP and non-CHD patients.

Conclusions:

  • Increased PLTP activity is associated with depressed LV systolic function in a dose-dependent manner.
  • This association is independent of the presence or severity of coronary heart disease.
  • Higher PLTP activity is also linked to unstable coronary heart disease.