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Solid phase analytical derivatization as a sample preparation method.

Sanka N Atapattu¹, Jack M Rosenfeld

¹Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8S 4K1, Canada. sanka@wayne.edu

Journal of Chromatography. A

|April 3, 2013

Summary

This summary is machine-generated.

Solid phase analytical derivatization (SPAD) offers an efficient, eco-friendly method for sample preparation by combining extraction and derivatization. This review highlights SPAD

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Area of Science:

Analytical Chemistry
Sample Preparation Techniques

Background:

Analytical derivatization (AD) enhances sensitivity, selectivity, and chromatographic separation in analyses.
Solid phase analytical derivatization (SPAD) integrates extraction and derivatization for improved sample preparation.

Purpose of the Study:

To review the diverse applications of SPAD.
To explore SPAD's integration with various sample preparation methods.

Main Methods:

Review of literature on SPAD applications.
Focus on SPAD combined with solid phase extraction (SPE), ion exchange resins, solid phase microextraction (SPME), in-tube extraction, microfluidic devices, and hollow fiber extraction.

Main Results:

SPAD offers economical and low-organic-solvent consumption sample preparation.
SPAD is easily automated and applicable to complex matrices.
SPAD demonstrates versatility when coupled with multiple extraction techniques.

Conclusions:

SPAD is a valuable technique for efficient and green sample preparation in analytical chemistry.
The combination of SPAD with various extraction methods expands its applicability across diverse analytical challenges.