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Updated: May 12, 2026

Assaying Blood Cell Populations of the Drosophila melanogaster Larva
Published on: November 11, 2015
The Drosophila clotting system and its messages for mammals
Ulrich Theopold1, Robert Krautz, Mitchell S Dushay
1Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, 10691 Stockholm, Sweden.
Abstract:
Drosophila has been increasingly used as a model to study hemolymph clotting. Proteomics and bioinformatics identified candidate clotting-factors, several of which were tested using genetics. Mutants and lines with reduced expression of clotting-factors show subtle effects after wounding, indicating that sealing wounds may rely on redundant mechanisms. More striking effects are observed after infection, in particular when a natural infection model involving entomopathogenic nematodes is used. When translated into mammalian models these results reveal that mammalian blood clots serve a similar immune function, thus providing a new example of the usefulness of studying invertebrate models.
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