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Related Experiment Video

Updated: May 12, 2026

Non-Intubated Video-Assisted Thoracoscopic Surgery

Non-Intubated Video-Assisted Thoracoscopic Surgery

Published on: May 26, 2023

Low-dose spinal morphine for post-thoracotomy pain: a prospective randomized study.

Sirilak Suksompong¹, Ploynaree Pongpayuha, Warunya Lertpaitoonpan

¹Department of Anesthesiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. sirilak.suk@mahidol.ac.th

Journal of Cardiothoracic and Vascular Anesthesia

|April 3, 2013

Summary

For post-thoracotomy pain, 0.2 mg of spinal morphine is as effective as 0.3 mg. Higher doses do not reduce opioid use but may increase the risk of respiratory depression.

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Last Updated: May 12, 2026

Non-Intubated Video-Assisted Thoracoscopic Surgery

Non-Intubated Video-Assisted Thoracoscopic Surgery

Published on: May 26, 2023

Area of Science:

Anesthesiology
Thoracic Surgery
Pain Management

Background:

Post-thoracotomy pain management is crucial for patient recovery.
Spinal morphine is an effective option for managing severe postoperative pain.
Optimizing spinal morphine dosage is essential to balance efficacy and safety.

Purpose of the Study:

To compare the efficacy and safety of 0.2 mg versus 0.3 mg of spinal morphine in patients experiencing post-thoracotomy pain.
To evaluate the impact of different spinal morphine doses on patient-controlled analgesia requirements and side effects.

Main Methods:

Prospective, randomized, double-blind study conducted at a university hospital and tertiary referral center.
Forty patients undergoing thoracotomy for lung resection were enrolled.
Participants received either 0.2 mg or 0.3 mg of spinal morphine prior to general anesthesia.

Main Results:

No statistically significant differences were observed in 24-hour meperidine consumption between the 0.2 mg and 0.3 mg spinal morphine groups.
Pain relief, time to recovery milestones (drinking, eating, sitting, walking), and pain scores were similar across both dosage groups.
Incidences of side effects, including sedation, nausea, vomiting, and pruritus, did not differ significantly between the groups.

Conclusions:

0.2 mg of spinal morphine is as effective as 0.3 mg for managing post-thoracotomy pain in patients undergoing elective thoracotomy.
Increasing spinal morphine dosage beyond 0.2 mg does not lead to reduced postoperative opioid consumption.
A higher dose of 0.3 mg spinal morphine may be associated with a rare risk of respiratory depression.