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Updated: May 12, 2026
08:46
Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
Published on: December 9, 2015
Tamoxifen resistance: from bench to bedside
Marjolein Droog1, Karin Beelen, Sabine Linn
1Department of Molecular Pathology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
European Journal of Pharmacology
|April 3, 2013
Summary
Many breast cancer patients do not respond to tamoxifen. This review discusses cell biological biomarkers that could predict tamoxifen resistance, aiding clinical decisions for better treatment selection.
Area of Science:
- Oncology
- Pharmacology
- Translational Medicine
Background:
- Tamoxifen is a targeted therapy for estrogen receptor alpha-positive breast cancer.
- A significant number of patients do not benefit from tamoxifen treatment.
- Numerous cell biological studies have identified potential biomarkers for tamoxifen sensitivity.
Purpose of the Study:
- To review cell biological biomarkers associated with tamoxifen resistance.
- To discuss the clinical implications of these biomarkers.
- To guide clinical scientists in selecting biomarkers for validation in patient samples.
Main Methods:
- Literature review of cell biological studies on tamoxifen resistance biomarkers.
- Analysis of potential clinical translation pathways for identified biomarkers.
Main Results:
- Several cell biological biomarkers for tamoxifen resistance have been identified in preclinical studies.
- The transition of these biomarkers into clinical practice remains a challenge.
- The clinical utility of these biomarkers requires validation using patient tumor samples.
Conclusions:
- Effective selection of biomarkers is crucial for successful clinical translation.
- Validated biomarkers can improve treatment selection for breast cancer patients.
- This review aims to facilitate the integration of research findings into clinical practice.
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