Related Experiment Video
Updated: May 12, 2026

07:15
Orthotopic Hind Limb Transplantation in the Mouse
Published on: February 12, 2016
Historical overview of transplantation
Clyde F Barker1, James F Markmann
1Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA. clyde.barker@uphs.upenn.edu
Cold Spring Harbor Perspectives in Medicine
|April 3, 2013
Summary
The history of organ transplantation, excluding myths, spans the last 60 years due to early failures. This summary highlights key transplantation landmarks and their varying impacts over time.
Area of Science:
- * Transplantation science and medical history.
- * History of medicine and surgical innovation.
Background:
- * Organ transplantation history is largely confined to the last 60 years, following a period of consistent failure.
- * Comprehensive historical accounts are extensive, necessitating a focus on select pivotal moments.
Observation:
- * The narrative of modern transplantation is rich but complex, with numerous documented events.
- * Key developments in transplantation science have had varied recognition, with some immediate impacts and others delayed.
- * The historical record includes overlooked discoveries and impactful findings lacking biological significance.
Findings:
- * Transplantation history is marked by 'landmarks' with diverse levels of immediate and long-term significance.
- * The evolution of transplantation involved both recognized breakthroughs and forgotten or misjudged findings.
- * Perspectives on transplantation's historical milestones vary among pioneers and their contemporaries.
Implications:
- * Understanding transplantation's historical trajectory requires careful selection and contextualization of key events.
- * The subjective nature of historical accounts from pioneers adds complexity to interpreting transplantation's past.
- * Recognizing the selective nature of historical documentation is crucial for a nuanced understanding of transplantation's progress.
Related Concept Videos
Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Tissue Transplantation
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant II: Surgical Procedure
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

