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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Peripheral artery disease and kidney function in hypertensive patients
Carolina Sarmento1, Telmo Pereira, João Maldonado
1Departamento de Cardiopneumologia, Escola Superior de Tecnologia da Saúde de Coimbra, Coimbra, Portugal.
Arquivos Brasileiros De Cardiologia
|April 3, 2013
Summary
Peripheral arterial disease (PAD) is linked to reduced kidney function in hypertensive patients. Early detection of chronic kidney disease (CKD) and PAD through routine screening can help reduce cardiovascular risk.
Area of Science:
- Cardiology
- Nephrology
- Hypertension Research
Background:
- Peripheral arterial disease (PAD) significantly increases cardiovascular event risk.
- PAD is highly prevalent in individuals with kidney disease, a shared cardiovascular risk factor.
- Hypertension exacerbates the risks associated with both PAD and kidney disease.
Purpose of the Study:
- To investigate the association between peripheral arterial disease (PAD) and renal function.
- Focus on hypertensive patients to understand this specific high-risk population.
Main Methods:
- Utilized ankle-brachial index (ABI) to assess PAD presence (ABI < 0.9).
- Estimated glomerular filtration rate (eGFR) was used to evaluate renal function.
- Analyzed data from 909 individuals with arterial hypertension.
Main Results:
- 8% of subjects had abnormal ABI, indicating PAD.
- Chronic kidney disease (CKD) prevalence was significantly higher in those with abnormal ABI (23.4%) versus normal ABI (11.2%).
- Lower eGFR showed an independent association with increased likelihood of PAD (OR 0.987).
Conclusions:
- An independent association exists between PAD and chronic kidney disease (CKD).
- Routine ABI screening in hypertensive patients with kidney disease can identify subclinical PAD.
- Early identification facilitates interventions to mitigate cardiovascular risk.
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