Related Experiment Video
Updated: May 12, 2026
05:17
Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
Published on: October 10, 2025
Lung cancer in China: challenges and interventions
Jun She1, Ping Yang2, Qunying Hong1
1Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Chest
|April 3, 2013
Summary
Lung cancer is now the leading cause of cancer death in China, with mortality rates soaring over 460% in 30 years. Key risk factors include smoking and pollution, necessitating public education and targeted interventions for lung cancer prevention and early detection.
Area of Science:
- Oncology
- Public Health
- Epidemiology
Background:
- Lung cancer has surpassed liver cancer as the leading cause of cancer mortality in China since 2008.
- The lung cancer mortality rate has increased by 464.84% over the past three decades, presenting a significant public health challenge.
- This escalating burden impacts patients, healthcare providers, and society, underscoring the need for comprehensive analysis and intervention strategies.
Purpose of the Study:
- To systematically review and analyze lung cancer incidence, mortality, economic burden, risk factors, and intervention effectiveness in China.
- To identify geographical variations in lung cancer incidence and mortality across different regions of China.
- To provide evidence-based recommendations for public health policies and clinical practices related to lung cancer in China.
Main Methods:
- A systematic review of published literature on lung cancer in China from 1990 to 2011.
- Analysis of incidence and mortality data, including geographical disparities and demographic variations (gender, region).
- Identification and evaluation of major risk factors (smoking, environmental pollution) and intervention strategies.
Main Results:
- Lung cancer incidence exhibits significant regional variation, with higher risks observed in eastern China, particularly among women.
- Crude lung cancer mortality rates in 2008 were 47.51/100,000 for men and 22.69/100,000 for women, with Shanghai reporting the highest rates and Tibet/Ningxia the lowest.
- Smoking and environmental pollution are identified as primary risk factors contributing to the high burden of lung cancer in China.
Conclusions:
- Public education on lung cancer prevention and early detection is crucial.
- Targeted interventions to reduce smoking rates and mitigate environmental risks are essential.
- Adoption and adaptation of standardized treatment protocols are recommended for improving lung cancer care in China.
Related Concept Videos
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
01:30Chronic Obstructive Pulmonary Disease-V: Nursing Management
Nursing management of Chronic Obstructive Pulmonary Disease (COPD) is crucial for providing thorough care and support to patients. Nurses play an integral role in this process through detailed assessment, careful planning, targeted interventions, and ongoing evaluation. Here's an overview of the critical steps in nursing management for COPD.
Assessment
Assessment
01:29Chronic Obstructive Pulmonary Disease-V: Management
Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
Smoking Cessation
02:49Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
01:20COPD: Pathogenesis and Clinical Features
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...