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Published on: July 31, 2015
Delivery of plasmid DNA to mammalian cells using polymer-gold nanorod assemblies
James Ramos1, Huang-Chiao Huang, Kaushal Rege
1School of Biological and Health Systems & Chemical Engineering, Center for the Convergence of Physical Science and Cancer Biology, Arizona State University, Tempe, AZ, USA.
Abstract:
Functionalized and surface-modified gold nanorods (GNRs) have emerged as promising vehicles for the delivery of several therapeutic agents. Ease of functionalization, increased stability, biocompatibility, and size-dependent plasmonic properties make gold nanorods attractive in sensing, imaging, and delivery to different cellular types. Here, we demonstrate the use of polyelectrolyte-coated GNRs (PE-GNRs) for delivering plasmid DNA to mammalian cells for transgene expression.
