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Related Experiment Video

Updated: May 12, 2026

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

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Reference ranges of coagulation tests.

Oliver Speer¹, Markus Schmugge, Claudia Metzger

¹Division of Haematology, University Children's Hospital, Zurich, Switzerland.

Methods in Molecular Biology (Clifton, N.J.)

|April 3, 2013

Summary

This summary is machine-generated.

Accurate reference ranges are crucial for diagnosing medical conditions using clinical measurements. This guide details methods for determining reliable reference ranges for coagulation tests, considering various influencing factors.

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Area of Science:

Clinical Laboratory Science
Hematology

Background:

Accurate reference ranges are essential for interpreting clinical laboratory test results and aiding diagnosis.
Establishing precise reference ranges is a complex and demanding process.
Coagulation assays are critical for diagnosing and monitoring hemostatic disorders.

Purpose of the Study:

To provide a comprehensive guide on the analysis of reference values and determination of reference ranges for coagulation assays.
To discuss the theoretical and practical aspects of establishing reliable reference ranges.
To highlight factors influencing reference values in coagulation testing.

Main Methods:

Detailed step-by-step procedures for reference range determination.
Analysis of preanalytical and analytical factors affecting coagulation assay results.
Examination of age-dependent variations in reference values.

Main Results:

The chapter outlines a systematic approach to calculating and validating reference ranges.
Identifies key preanalytical and analytical variables that impact coagulation test results.
Discusses the significance of age as a factor in reference value interpretation.

Conclusions:

Accurate reference ranges are vital for correct interpretation of coagulation tests.
Consideration of preanalytical, analytical, and demographic factors is necessary for establishing robust reference ranges.
This work provides a framework for improving the accuracy and clinical utility of coagulation reference ranges.