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Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
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Carbapenem-resistant Enterobacteriaceae: a menace to our most vulnerable patients

Federico Perez1, David Van Duin

  • 1Research Service, Louis Stokes Cleveland Department, of Veterans Affairs Medical Center, Cleveland, OH, USA.

Cleveland Clinic Journal of Medicine
|April 3, 2013
PubMed

Insights

Carbapenem-resistant Enterobacteriaceae (CRE) cause severe hospital infections. Understanding CRE resistance, spread, and treatment is crucial for healthcare safety.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Antimicrobial Resistance

Background:

  • Carbapenem-resistant Enterobacteriaceae (CRE) pose a significant threat to public health.
  • CRE infections are associated with high morbidity and mortality in hospitalized patients.
  • The rise of CRE necessitates urgent strategies for infection control.

Purpose of the Study:

  • To review the mechanisms underlying carbapenem resistance in Enterobacteriaceae.
  • To examine the dissemination patterns and clinical impact of CRE.
  • To identify challenges in the detection, treatment, and control of CRE infections.

Main Methods:

  • Literature review of studies on carbapenem resistance mechanisms.
  • Analysis of epidemiological data on CRE dissemination.
  • Review of clinical case reports and treatment guidelines.

Main Results:

  • Enterobacteriaceae acquire carbapenem resistance through various genetic mechanisms.
  • CRE strains are spreading globally, leading to difficult-to-treat infections.
  • Effective detection, treatment, and control strategies are limited.

Conclusions:

  • CRE represent a critical challenge in healthcare settings.
  • Further research into novel therapeutic and preventative measures is essential.
  • Multidisciplinary approaches are required to combat the spread of CRE.

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