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Updated: May 12, 2026

Safety Precautions and Operating Procedures in an (A)BSL-4 Laboratory: 4. Medical Imaging Procedures
Published on: October 3, 2016
Appropriate and safe use of diagnostic imaging
Brian K Crownover1, Jennifer L Bepko
1Nellis Air Force Base Family Medicine Residency, Nellis Air Force Base, NV 89191, USA. brian.crownover@us.af.mil
Diagnostic imaging risks include cancer from radiation and nephrogenic systemic fibrosis. Using imaging appropriately based on guidelines can minimize these risks, especially with computed tomography (CT) scans.
Area of Science:
- Radiology
- Medical Imaging
- Radiation Safety
Background:
- Diagnostic imaging use has surged, increasing radiation exposure and associated risks like cancer.
- Gadolinium contrast media poses a risk of nephrogenic systemic fibrosis in patients with advanced chronic kidney disease.
Purpose of the Study:
- To review the risks associated with diagnostic imaging, including radiation exposure and contrast media complications.
- To provide guidance on appropriate imaging utilization to mitigate potential harms.
Main Methods:
- Review of current literature on diagnostic imaging risks and benefits.
- Analysis of trends in imaging volume and radiation exposure.
- Evaluation of specific imaging modalities and their indications.
Main Results:
- Computed tomography (CT) exposure is predicted to cause 2% of future cancers.
- Diffusion-weighted MRI is superior to CT for stroke evaluation between 3-24 hours.
- Specific imaging techniques offer advantages for appendicitis, cholecystitis, and urolithiasis in pregnancy.
Conclusions:
- Appropriate use of diagnostic imaging, guided by clinical guidelines, is crucial for risk reduction.
- Certain imaging modalities should be avoided or used judiciously in specific patient populations (e.g., CKD, chronic back pain).
- Evidence does not support the use of whole-body scanning.
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