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Toxicity Testing in Animals

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...

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Related Experiment Video

Updated: May 12, 2026

Safety Precautions and Operating Procedures in an (A)BSL-4 Laboratory: 4. Medical Imaging Procedures

Safety Precautions and Operating Procedures in an (A)BSL-4 Laboratory: 4. Medical Imaging Procedures

Published on: October 3, 2016

Laboratory animals as veterinary patients

Steven M Niemi¹

¹Department of Research Management, Massachusetts General Hospital, Boston, MA 02114, USA. sniemi@partners.org

Journal of the American Veterinary Medical Association

|April 4, 2013

Summary

No abstract available in PubMed .

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