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Updated: May 12, 2026

Quantification of Cerebral Vascular Architecture using Two-photon Microscopy in a Mouse Model of HIV-induced Neuroinflammation
Published on: January 12, 2016
The aggregate effects of multiple comorbid risk factors on cognition among HIV-infected individuals
Sapna M Patel1, April D Thames, Natalie Arbid
1Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA. smpatel@mednet.ucla.edu
Abstract:
This study developed and then cross-validated a novel weighting algorithm based on multiple comorbid risk factors (stimulant use, vascular disease, hepatitis C, HIV disease severity, cognitive reserve) to predict cognitive functioning among 366 HIV+ adults. The resultant "risk severity score" was used to differentially weight, as a function of age, the impact and magnitude of multiple risk factors on cognition. Among older adults (≥50 years) the risk severity index was differentially predictive of learning/memory and verbal fluency, whereas among younger adults it was linked to working memory and executive function. Cognitive reserve was found to be the most robust predictor of neurocognition.
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