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Related Concept Videos

Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...

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Quantifying the Antifungal Activity of Peptides Against Candida albicans
06:45

Quantifying the Antifungal Activity of Peptides Against Candida albicans

Published on: January 13, 2023

Nylon-3 polymers with selective antifungal activity.

Runhui Liu1, Xinyu Chen, Zvi Hayouka

  • 1Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.

Journal of the American Chemical Society
|April 4, 2013
PubMed
Summary

New nylon-3 polymers show potent antifungal activity against Candida albicans while exhibiting low toxicity to mammalian cells and red blood cells. This breakthrough offers a promising avenue for developing selective antifungal agents.

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Quantifying the Antifungal Activity of Peptides Against Candida albicans
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Published on: January 13, 2023

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08:54

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Published on: February 14, 2018

Area of Science:

  • Polymer chemistry
  • Antimicrobial research
  • Mycology

Background:

  • Host-defense peptides selectively inhibit bacterial growth with minimal mammalian cell toxicity.
  • Synthetic polymers can mimic antibacterial selectivity, but achieving similar fungal selectivity is challenging due to eukaryotic fungal pathogens.

Purpose of the Study:

  • To develop novel nylon-3 polymers with potent and selective antifungal activity.
  • To evaluate the efficacy and safety profile of these new polymers against fungal pathogens and mammalian cells.

Main Methods:

  • Synthesis of novel nylon-3 polymers utilizing a unique subunit.
  • Antifungal activity testing using minimum inhibitory concentration (MIC) against Candida albicans.
  • Mammalian cell toxicity assays (3T3 fibroblasts) and hemolysis assays to determine selectivity (IC10 and HC10 values).

Main Results:

  • The novel nylon-3 polymers demonstrated potent antifungal activity against Candida albicans, with a minimum inhibitory concentration (MIC) of 3.1 μg/mL.
  • These polymers exhibited favorable selectivity, showing low toxicity to 3T3 fibroblasts (IC10 > 400 μg/mL) and minimal hemolysis (HC10 > 400 μg/mL).

Conclusions:

  • Nylon-3 polymers based on a novel subunit are effective against Candida albicans.
  • These polymers present a promising platform for developing selective antifungal therapeutics with a wide safety margin.