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The role of depression in medication adherence among heart failure patients

Hsin-Yi Jean Tang1, Steven L Sayers, Guy Weissinger

  • 1College of Nursing, Seattle University, Seattle, WA, USA.

Clinical Nursing Research
|April 4, 2013
PubMed

Insights

Depression in heart failure patients is linked to self-reported poor medication adherence, but objective measures show no significant difference. This highlights potential biases in patient reporting for adherence in depression management.

Area of Science:

  • Cardiology
  • Psychiatry
  • Health Psychology

Background:

  • Depression is prevalent in heart failure (HF) patients.
  • Depression may impact medication adherence, but findings are conflicting.
  • Accurate assessment of medication adherence is crucial for HF management.

Purpose of the Study:

  • To investigate the association between depression and medication adherence in Stage C heart failure patients.
  • To compare self-reported and objectively measured medication adherence in depressed versus nondepressed HF patients.

Main Methods:

  • 244 adults with Stage C HF participated.
  • Self-reported adherence was measured using the Basel Assessment of Adherence Scale (BAAS).
  • Objective adherence data were collected via the electronic Medication Event Monitoring System (MEMS).
  • Depression was assessed using the Patient Health Questionnaire (PHQ-9).

Main Results:

  • A significant difference in self-reported medication nonadherence was found between depressed and nondepressed participants (p = .008).
  • No significant difference in objectively measured medication nonadherence was observed (p = .72).
  • Depressed patients were 2.3 times more likely to self-report poor adherence (p = .006).

Conclusions:

  • Depression in HF patients is associated with higher rates of self-reported medication nonadherence.
  • Objective adherence measures do not corroborate self-reported nonadherence in this population.
  • Findings suggest a potential overestimation of nonadherence by depressed HF patients, impacting treatment strategies.

Keywords:
depressionheart failuremajor depressive disordersmedication adherence

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