Blockage of peripheral NPY Y1 and Y2 receptors modulates barorefex sensitivity of diabetic rats

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Updated: May 12, 2026

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice
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Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice

Published on: February 14, 2021

Jing Liu1, Ning Wang, Fang Xie

  • 1Department of Pharmacology, Harbin Medical University (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin, Heilongjiang Province, China.

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
|April 4, 2013
PubMed
Abstract

Insights

In diabetic rats, blocking neuropeptide Y receptors Y1R and Y2R did not improve baroreceptor reflex sensitivity (BRS). However, this blockade worsened cardiac function, indicating these receptors

Area of Science:

  • Cardiovascular Physiology
  • Endocrinology
  • Pharmacology

Background:

  • Abnormal baroreceptor reflex sensitivity (BRS) and elevated plasma neuropeptide Y (NPY) are common in diabetes.
  • NPY Y1 receptor (Y1R) and NPY Y2 receptor (Y2R) roles in regulating BRS in diabetic conditions are unclear.

Purpose of the Study:

  • To investigate the involvement of NPY Y1R and Y2R in the regulation of BRS in diabetic rats.
  • To assess the impact of Y1R and Y2R antagonists on cardiac function and lipid profiles in diabetic rats.

Main Methods:

  • Diabetes mellitus (DM) and hyperlipidemia were induced in rats using a high-fat/sugar diet and streptozocin (STZ).
  • Specific Y1R (BIBP 3226) and Y2R (BIIE 0246) antagonists were administered via mini-osmotic pumps for 4 weeks.
  • Measurements included systolic blood pressure (SBP), heart rate (HR), BRS, cardiac function (LVSP, LVEDP, dp/dtmax), plasma NPY, and lipid levels.

Main Results:

  • Antagonist treatments normalized total cholesterol (TC) and LDL-C, and reduced HDL-C in DM rats.
  • BIIE 0246 showed a trend towards reducing triglycerides (TG).
  • Neither antagonist significantly affected BRS, SBP, or HR but worsened cardiac function parameters (LVSP, LVEDP, +dp/dtmax, -dp/dtmax).

Conclusions:

  • Peripheral Y1R and Y2R inhibition does not influence impaired BRS in STZ-induced diabetic rats.
  • Blocking these receptors exacerbates cardiac dysfunction in diabetic rats with hyperlipidemia.
  • Y1R and Y2R may play a role in maintaining cardiac function under diabetic stress.

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