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Posttraumatic stress disorder: neurocircuitry and implications for potential deep brain stimulation
Alexander Taghva1, Chima Oluigbo, John Corrigan
1Center for Neuromodulation, Department of Neurosurgery, Ohio State University, Columbus, Ohio, USA. alextaghva@gmail.com
Stereotactic and Functional Neurosurgery
|April 4, 2013
Summary
Posttraumatic stress disorder (PTSD) is a difficult-to-treat condition affecting many. This review explores PTSD neurocircuitry and proposes deep brain stimulation as a potential neuromodulation strategy.
Area of Science:
- Neuroscience
- Psychiatry
- Neuromodulation
Background:
- Posttraumatic stress disorder (PTSD) is a prevalent and disabling psychiatric condition with limited treatment efficacy.
- Despite existing therapies, a significant percentage of patients remain symptomatic long-term.
- Neuroimaging studies suggest altered limbic and corticostriatopallidothalamocortical (CSPTC) circuitry in PTSD pathogenesis.
Purpose of the Study:
- To review the clinical features and neurocircuitry of PTSD.
- To propose a novel neuromodulation strategy for treating PTSD.
Main Methods:
- Review of clinical features and neuroimaging findings in PTSD.
- Exploration of deep brain stimulation's role in modulating CSPTC circuits.
Main Results:
- Identified key clinical characteristics of PTSD.
- Highlighted the involvement of specific neurocircuitry in PTSD.
- Proposed deep brain stimulation as a potential therapeutic avenue.
Conclusions:
- PTSD presents significant treatment challenges.
- Understanding CSPTC circuitry is crucial for PTSD.
- Neuromodulation, specifically deep brain stimulation, offers a promising strategy for PTSD treatment.
