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Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...

Models of Health Promotion and Illness Prevention II

Models of Health Promotion and Illness Prevention II

The person's health status fluctuates continually, varying from being in good health to becoming ill and returning to being healthy. To understand the concept of illness prevention, there are two models. First, the health-illness continuum model is a graphic representation of an individual's wellness. It states that a person is considered healthy in the absence of physical disease and the presence of good emotional health.
The agent-host-environment model states that disease results from...

Dimensions of Health and Illness

Dimensions of Health and Illness

The factors influencing the health-illness continuum can be internal or external and may or may not be under conscious control. They are related to the following eight human dimensions, and each dimension is interrelated to one other.

Drug Dosing: Obese Patients

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...

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Updated: May 12, 2026

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Obesity as a showcase for transdisciplinary research.

Lotte Holm¹, Peter Børker Nielsen, Peter Sandøe

¹University of Copenhagen, Copenhagen, Denmark.

|April 4, 2013

Summary

Obesity is a major global health issue with significant costs. Addressing this complex epidemic requires international scientific collaboration to broaden perspectives and find effective solutions.

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Last Updated: May 12, 2026

Multidisciplinary Approach to Obesity Management: A Case Report

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Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas

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Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

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Area of Science:

Public Health
Epidemiology
Metabolic Science

Background:

Obesity represents a significant global health challenge with substantial societal and individual economic burdens.
The escalating obesity epidemic necessitates a re-evaluation of current understanding and intervention strategies.

Purpose of the Study:

To advocate for a multidisciplinary approach to understanding and combating the global obesity epidemic.
To emphasize the need for broadened scientific perspectives on obesity as a complex phenomenon.

Main Methods:

This study is a conceptual analysis and synthesis of existing knowledge on obesity.
It involves a review of literature from various scientific disciplines to highlight the complexity of obesity.

Main Results:

Obesity is a multifaceted issue influenced by a wide range of biological, environmental, and socioeconomic factors.
Current approaches may be insufficient due to a lack of integrated, cross-disciplinary insights.

Conclusions:

A collaborative, international, and interdisciplinary effort is crucial for effectively addressing the obesity epidemic.
Broadening scientific perspectives is essential for developing comprehensive and sustainable solutions to the global obesity crisis.