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Updated: May 12, 2026

Long-Term Catheterization of the Intestinal Lymph Trunk and Collection of Lymph in Neonatal Pigs
Published on: March 5, 2016
Generalized lymphadenopathy in infancy; a case report
Mamishi Setareh1, Movahedi Zahra, Mohammadzadeh Vahid
1Pediatric Infectious Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran ; Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.
Background:
Rosai-Dorfman disease (RDD) is a rare disease of histiocytic cells, a cause of benign cervical lymphadenopathy (LAP) and massive generalized lymph node enlargement in children and adults. There are also some reports on involvement of other human body organs with or without LAP.
Case Presentation:
A 7-month-old infant with chief complaint of generalized massive LAP was referred to our center. RDD was diagnosed according to clinical manifestations and confirmed through histopathologic and immunoreactivity study on the obtained sample by cervical lymph node biopsy.
Conclusion:
RDD is not a malignant illness and lymph node enlargement most often decreases in its size happens without special treatment.
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