[Application for academic multicenter studies at German ethical review boards]
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Updated: May 12, 2026

Operating and Biocontainment Procedures of a Facility for Laboratory Mice with a Natural Microbiome: Immunophenotyping Procedure
Published on: December 13, 2024
Nicola Gökbuget1, Ralph Naumann,
1Universitäres Centrum für Tumorerkrankungen, Medizinische Klinik II, Hämatologie/Onkologie, Klinikum der Goethe-Universität, Frankfurt a.M., Deutschland. goekbuget@em.uni-frankfurt.de
Abstract:
Before the start of a clinical trial, approval by the responsible institutional ethical review board (IRB) is required. In Germany, nearly 50 independent IRBs may be responsible for the different participating sites of a multicenter study. In trials for rare diseases, the participation of many centers is required. Therefore, the application procedure for academic multicenter trials in malignant hematologic diseases is often a bureaucratic nightmare. Different aspects of IRB application and possible approaches for improvement are presented.
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