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Related Experiment Video

Updated: May 12, 2026

The Establishment of a Murine Maxillary Orthodontic Model

The Establishment of a Murine Maxillary Orthodontic Model

Published on: October 27, 2023

Intrauterine hormone effects on tooth dimensions.

D C Ribeiro¹, A H Brook, T E Hughes

¹School of Dentistry, The University of Adelaide, Adelaide, Australia, 5005.

Journal of Dental Research

|April 4, 2013

Summary

This summary is machine-generated.

Females in opposite-sex twin pairs had larger teeth, supporting the Twin Testosterone Transfer (TTT) hypothesis. This suggests intrauterine male hormones influence dental development and human tooth sexual dimorphism.

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Last Updated: May 12, 2026

The Establishment of a Murine Maxillary Orthodontic Model

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Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants

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Published on: March 29, 2018

Area of Science:

Human biology
Dental anthropology
Genetics

Background:

Human dentition exhibits sexual dimorphism influenced by genetic, epigenetic, and environmental factors.
The role of intrauterine male hormones in dental sexual dimorphism remains unclear.

Purpose of the Study:

To investigate the influence of intrauterine male hormones on dental development.
To test the Twin Testosterone Transfer (TTT) hypothesis by comparing tooth sizes in different twin types.

Main Methods:

Examined dental models of 134 females from opposite-sex dizygotic (DZOS), same-sex dizygotic (DZSS), and monozygotic (MZ) twin pairs.
Measured mesiodistal, buccolingual, crown height, and intercuspal dimensions of primary and permanent teeth using image analysis.

Main Results:

Females from DZOS twin pairs exhibited statistically significantly larger tooth crown size in both primary and permanent dentitions.
Crown height dimensions showed the most substantial increase in size in DZOS females.
Findings support the Twin Testosterone Transfer (TTT) hypothesis.

Conclusions:

Intrauterine male hormone exposure, including testosterone surges, influences dental development.
The Y chromosome and intrauterine male hormone levels differentially affect tooth dimensions, contributing to human tooth sexual dimorphism.