Related Experiment Video
Updated: May 12, 2026

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
Published on: October 21, 2022
Circulating miRNA profile in HCV infected serum: novel insight into pathogenesis
Shivaprasad Shwetha1, K Gouthamchandra, Madhavi Chandra
1Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
Abstract:
Changes in circulating miRNA profiles have been associated with different diseases. Here we demonstrate the circulating miRNA profile in serum of HCV infected individuals using a microRNA array that profiles the expression of 940 miRNAs. Serum samples from two HCV genotype - 1 and two HCV genotype - 3 infected individuals were compared with healthy controls. Expression levels of miR-134, miR-198, miR-320c and miR-483-5p that were commonly upregulated in case of both genotypes were validated in 36 individual patient serum samples. Serum miR-134, miR-320c and miR-483-5p were significantly upregulated during HCV infection. miR-320c and miR-483-5p were also upregulated in HCV- JFH1 infected cells and cell culture supernatant. Pathway analysis of putative target genes of these miRNAs indicated involvement of PI3K-Akt, NFKB and MAPK signaling pathways. Results revealed novel insights on the role of circulating miRNAs in mediating pathogenesis in HCV-infected cells.
Related Concept Videos
MicroRNAs
MicroRNAs
MicroRNAs
Hepatitis
Viral Hepatitis I: Introduction
Cirrhosis II: Pathophysiology

