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Related Experiment Video

Updated: May 12, 2026

Dithranol as a Matrix for Matrix Assisted Laser Desorption/Ionization Imaging on a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer

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Shorthand notation for lipid structures derived from mass spectrometry.

Gerhard Liebisch¹, Juan Antonio Vizcaíno², Harald Köfeler³

¹Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany;.

Journal of Lipid Research

|April 4, 2013

Summary

A new shorthand notation standardizes lipid species annotation from mass spectrometry. This practical method enhances data interpretation and database construction for lipidomics research.

Keywords:

abbreviation fatty acids glycerolipids glycerophospholipids lipidomics nomenclature sphingolipids sterols

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Quantitative Analysis of the Cellular Lipidome of Saccharomyces Cerevisiae Using Liquid Chromatography Coupled with Tandem Mass Spectrometry

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Published on: March 8, 2020

Area of Science:

Lipidomics
Mass Spectrometry
Structural Biology

Background:

Mass spectrometry generates high-throughput lipidomics data.
Current annotation lacks detailed structural information, including stereochemistry.
Existing nomenclature, like LIPID MAPS, requires further structural definition.

Purpose of the Study:

To develop a standardized, practical shorthand notation for lipid species.
To augment existing lipid nomenclature with detailed structural information.
To facilitate accurate reporting and database construction from mass spectrometry data.

Main Methods:

Developed rules for lipid species annotation based on common, accepted terms.
Extended the LIPID MAPS terminology with lower-level structural details.
Created shorthand notation for glycerophospholipids, fatty acids/acyls, glycerolipids, sphingolipids, and sterols.

Main Results:

A defined shorthand notation system for reporting lipid structures was established.
The notation addresses limitations in mass spectrometry data, such as fatty acid differentiation and bond types.
The system is applicable to various lipid classes and mass spectrometry resolutions.

Conclusions:

The proposed shorthand notation offers a standardized methodology for lipid species reporting.
This facilitates improved data consistency and interoperability in lipidomics.
The notation supports the development of comprehensive lipid databases.