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Updated: May 12, 2026

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
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Published on: September 28, 2022

Interpreting the Epstein-Barr Virus (EBV) epigenome using high-throughput data.

Aaron Arvey1, Italo Tempera, Paul M Lieberman

  • 1Memorial Sloan Kettering Cancer Center, NY, USA. aarvey@cbio.mskcc.org

Viruses
|April 4, 2013
PubMed
Summary
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Epstein-Barr virus (EBV) DNA undergoes significant epigenetic changes. Analyzing genome-wide data reveals insights into host and viral chromosome structure and epigenetic modifications in latent EBV infections.

Area of Science:

  • Virology
  • Epigenetics
  • Genomics

Background:

  • The Epstein-Barr virus (EBV) possesses a double-stranded DNA genome.
  • Latent EBV infection occurs in human lymphoblastoid and other cell lines.
  • Extensive epigenetic regulation governs the EBV genome.

Purpose of the Study:

  • To analyze genome-wide data sets on latent EBV infections.
  • To gain new insights into host and viral chromosome structure and epigenetic modifications.
  • To understand chromatin structure and transcription factor binding on latent EBV genomes.

Main Methods:

  • Mapping of large consortium and individual lab generated genome-wide data sets.
  • Analysis of epigenetic modifications and chromatin structure.
  • Investigating transcription factor binding patterns.

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Related Experiment Videos

Last Updated: May 12, 2026

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
09:14

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Published on: September 28, 2022

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
08:44

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
06:38

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines

Published on: November 8, 2011

Main Results:

  • Identification of important information on host and viral chromosome organization.
  • Detailed insights into epigenetic modifications on latent EBV genomes.
  • Understanding of colocalization of histone modifications and transcription factors at regulatory loci.

Conclusions:

  • Epigenetic regulation plays a crucial role in the biology and control of EBV.
  • Mapping and analysis of genome-wide data provide a deeper understanding of latent EBV.
  • Chromatin structure and transcription factor binding are key to EBV regulation.