Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...

Type II Diabetes I: Introduction

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...

Type II Diabetes II: Pathophysiology

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.

Diabetes: Management and Pharmacotherapy

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...

Type I Diabetes II: Pathophysiology

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Communication patterns in families affected by parental cancer from the healthy parents' perspective-process evaluation of the complex intervention Family-SCOUT.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2024

Same author

Effectiveness of a comprehensive support program for families with parental cancer (Family-SCOUT): results of a multicenter non-randomized controlled trial.

ESMO open·2024

Same author

Development of a shared decision-making intervention to improve drug safety and to reduce polypharmacy in frail elderly patients living at home.

PEC innovation·2023

Same author

Editorial: Insights in exercise and diabetes management.

Frontiers in endocrinology·2022

Same author

Social media attention and citations of published outputs from re-use of clinical trial data: a matched comparison with articles published in the same journals.

BMC medical research methodology·2021

Same author

Effects of a Brief Web-Based "Social Norms"-Intervention on Alcohol, Tobacco and Cannabis Use Among German University Students: Results of a Cluster-Controlled Trial Conducted at Eight Universities.

Frontiers in public health·2021

Search research articles

Related Experiment Video

Updated: May 12, 2026

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

[Prevention of Type 2 Diabetes: Evidence-Based Patient Information--A Randomised Controlled Trial].

J Genz¹, B Haastert², H Müller³

¹Deutsches Diabetes-Zentrum, Leibniz-Institut an der Heinrich-Heine-Universität Düsseldorf, Institut für Biometrie und Epidemiologie/Institut für Klinische Diabetologie.

Gesundheitswesen (Bundesverband Der Arzte Des Offentlichen Gesundheitsdienstes (Germany))

|April 4, 2013

Summary

Newly developed online evidence-based patient information (EBPI) improved knowledge of elevated glucose levels. However, it also increased patient decisional conflict, reducing the intention for metabolic screening.

Related Experiment Videos

Last Updated: May 12, 2026

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

Area of Science:

Diabetes prevention research
Health communication
Patient decision-making

Background:

Subthreshold elevated blood glucose requires effective patient information for primary prevention.
Informed decision-making is crucial for patient engagement in diabetes prevention strategies.
Current patient information may not adequately address complex screening and treatment decisions.

Purpose of the Study:

To compare the impact of online evidence-based patient information (EBPI) versus standard information on informed decision-making regarding elevated blood glucose and diabetes prevention.
To evaluate how EBPI influences patient knowledge, decisional conflict, and attitudes towards screening and treatment.

Main Methods:

A comparative study design was employed.
Participants received either newly developed online EBPI or standard patient information.
Outcomes measured included patient knowledge, decisional conflict, attitudes, and intention for metabolic screening.

Main Results:

Online EBPI significantly enhanced patient knowledge regarding elevated blood glucose levels.
EBPI led to increased decisional conflict among patients concerning screening and treatment options.
A notable decrease in the intention to undergo metabolic screening was observed in the EBPI group.

Conclusions:

While online EBPI improves knowledge, it may inadvertently increase patient uncertainty and hesitation towards recommended screening and interventions.
Further refinement of EBPI is needed to balance knowledge provision with decision support, particularly for primary diabetes prevention.
The findings highlight the complex interplay between information, patient decision-making, and engagement in preventative health behaviors.