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Globular Proteins

Globular Proteins

In organisms, proteins are the most abundant macromolecules. They act as the building blocks of life and play various crucial roles in the body. Proteins can be broadly classified into two distinct subtypes based on their shape and solubilities: globular proteins and fibrous proteins.
Globular proteins serve many important physiological functions, such as acting as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be soluble in the aqueous...

Globular and Fibrous Proteins

Globular and Fibrous Proteins

Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities.
Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...

Globular and Fibrous Proteins

Globular and Fibrous Proteins

Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities.
Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...

Drug Binding to Blood Components

Drug Binding to Blood Components

When drugs enter systemic circulation, they interact with various components of the blood, including proteins such as human serum albumin (HSA), α1-acid glycoprotein (AAG), lipoproteins, globulins, and red blood cells (RBCs).
HSA is the most abundant plasma protein and is vital in drug binding. It contains distinct drug-binding sites, with different drugs exhibiting affinity for specific sites. There are three main drug-binding domains for HSA: sites I, II, and III. These domains are further...

Drug Distribution: Tissue Binding

Drug Distribution: Tissue Binding

Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
For...

Transcytosis of IgG

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...

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Related Experiment Video

Updated: May 12, 2026

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding

Published on: September 21, 2011

An active role for steroid-binding globulins: an update.

J D Caldwell¹, G F Jirikowski

¹LECOM - Pharmacology, Erie, Pennsylvania 16509, USA. jcaldwell@lecom.edu

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme

|April 4, 2013

Summary

Steroid-binding globulins actively influence steroid actions. Recent research has advanced understanding of their location, physiological roles, and interactions with membrane receptors.

Area of Science:

Endocrinology
Molecular Biology
Cell Biology

Background:

Steroid-binding globulins (SBG) were previously explored for their role in steroid action.
Significant advancements have been made in the 7 years since the last focused review.

Purpose of the Study:

To review progress in understanding SBG
To discuss the identification of SBG locations and physiological actions
To highlight the discovery of a membrane-associated receptor for SBG

Main Methods:

Literature review of recent research on SBG
Analysis of studies identifying SBG localization
Examination of research on SBG-mediated steroid actions

Main Results:

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Last Updated: May 12, 2026

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SBG are confirmed to play active roles in steroid actions.
Progress has been made in pinpointing the cellular locations of SBG.
A membrane-associated receptor for a binding protein has been identified.

Conclusions:

Steroid-binding globulins are integral to steroid hormone activity.
The identification of a membrane receptor opens new avenues for research.
Further investigation into SBG-receptor interactions is warranted.