Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aneurysm I: Introduction01:30

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
Increased Intracranial Pressure ll: Pathophysiology01:29

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MAG-EX study protocol: magnetic stent versus stent on extraction string in patients after ureteroscopy-a multi-centre randomised controlled trial.

Translational andrology and urology·2026
Same author

Treatment of High-Risk Biochemically Recurrent Prostate Cancer with Enzalutamide in Combination with Leuprolide: Secondary End Points from the EMBARK Trial: Erratum.

The Journal of urology·2026
Same author

Ten Year Update on the Online and Social Media Presence of Australian and New Zealand Urologists.

ANZ journal of surgery·2026
Same author

Angioarchitectural features of hemorrhagic presentation of brain arteriovenous malformations: A multivariate and explainable machine learning study.

Neuroradiology·2026
Same author

Aneurysm Morphology Based on Conformal Geometry.

International journal for numerical methods in biomedical engineering·2026
Same author

Periprostatic Nerve Block During Transperineal Prostate Biopsy Under General Anaesthesia: Protocol for a Multicentre Pilot Randomised Controlled Trial.

Cancers·2026

Related Experiment Video

Updated: May 12, 2026

A Murine Model of Carotid Aneurysm Formation
03:47

A Murine Model of Carotid Aneurysm Formation

Published on: September 9, 2025

Physical factors effecting cerebral aneurysm pathophysiology.

Chander Sadasivan1, David J Fiorella, Henry H Woo

  • 1Department of Neurological Surgery, Stony Brook University Medical Center, 100 Nicolls Road, HSC T12, Room 080, Stony Brook, NY 11794-8122, USA.

Annals of Biomedical Engineering
|April 4, 2013
PubMed
Summary

Hemodynamic factors influence intracranial aneurysm development, but complex flow patterns alone don't fully explain aneurysm growth and rupture. The exact cause likely involves a combination of biochemical and biomechanical factors.

More Related Videos

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
09:14

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Published on: June 18, 2021

Related Experiment Videos

Last Updated: May 12, 2026

A Murine Model of Carotid Aneurysm Formation
03:47

A Murine Model of Carotid Aneurysm Formation

Published on: September 9, 2025

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
09:14

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Published on: June 18, 2021

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Cardiovascular Research

Background:

  • Intracranial aneurysms are associated with blood, wall, and hemodynamic factors.
  • Aneurysm distribution at the circle of Willis bifurcations suggests hemodynamic influence.

Purpose of the Study:

  • To review hemodynamic associations with intracranial aneurysms.
  • To explore vascular anatomy and wall structure in relation to hemodynamics.

Main Methods:

  • Literature review focusing on hemodynamic factors.
  • Analysis of studies linking flow patterns, pressure, and wall shear stress to aneurysm pathophysiology.

Main Results:

  • Hemodynamic factors correlate with intracranial aneurysm distribution.
  • Complex, slow flow patterns are linked to aneurysm growth and rupture.
  • Mechanical explanations alone are insufficient to explain aneurysm causation.

Conclusions:

  • Hemodynamic factors are necessary but not sufficient for aneurysm causation.
  • The ultimate cause of intracranial aneurysms is likely multifactorial, involving biochemical and biomechanical interactions.