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Prevalence of helicobacter pylori infection in children, a population-based cross-sectional study in west iran

Soltani Jafar1, Amirzadeh Jalil, Nahedi Soheila

  • 1Department of Pediatrics, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Iranian Journal of Pediatrics
|April 4, 2013
PubMed

Insights

Helicobacter pylori infection is highly prevalent in Kurdish children in Sanandaj, Iran, affecting 64.2% of those studied. Infection rates increase with age and family size, highlighting early childhood as a critical period for transmission.

Area of Science:

  • Pediatric Infectious Diseases
  • Gastroenterology
  • Epidemiology

Background:

  • Helicobacter pylori infection is common in developing countries, often acquired in childhood.
  • Childhood H. pylori infection is linked to later peptic ulcer and gastric cancer risks.
  • Noninvasive diagnostics are crucial for pediatric screening and epidemiological research.

Purpose of the Study:

  • To determine the prevalence of H. pylori infection among Kurdish children in Sanandaj, West Iran.
  • To investigate factors associated with H. pylori infection in this pediatric population.

Main Methods:

  • A Helicobacter Pylori Stool Antigen (HpSA) test was employed for H. pylori detection.
  • Data on age, sex, breastfeeding duration, and family size were collected via questionnaire.
  • 458 children aged 4 months to 15 years participated in the study.

Main Results:

  • The overall prevalence of H. pylori infection was 64.2% (294/458 children).
  • Infection prevalence significantly increased with child's age (P<0.001) and larger family size (P=0.005).
  • No significant correlation was found between H. pylori status and gender (P=0.6) or breastfeeding duration (P=0.8).

Conclusions:

  • H. pylori infection prevalence is notably high in children in Sanandaj.
  • Infection acquisition appears to start in early infancy and increases cumulatively with age.
Abstract

Keywords:
ChildrenHelicobacter PyloriIranPrevalence

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