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Related Experiment Videos

Contrast media used in cystourethrography. Experimental evaluation.

C M Siu, J S Dunbar, V J Wright

    Investigative Urology
    |May 1, 1975
    PubMed
    Summary

    Physiologic saline allows for greater bladder capacity compared to iodinated contrast media. Contrast media caused bladder mucosal changes, while saline did not persist beyond 6 hours.

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    Outflow from the nucleus accumbens to the pedunculopontine tegmental nucleus: a dissociation between locomotor activity and the acquisition of responding for conditioned reinforcement stimulated by d-amphetamine.

    Neuroscience·1994

    Area of Science:

    • Urology
    • Radiology
    • Histopathology

    Background:

    • Iodinated contrast media are frequently used in diagnostic imaging procedures.
    • Understanding the effects of these agents on bladder capacity and mucosa is crucial for patient safety.

    Purpose of the Study:

    • To compare the effects of five iodinated contrast media and saline on bladder capacity.
    • To evaluate the histological changes in the bladder mucosa following instillation of these agents.

    Main Methods:

    • Comparative study involving the instillation of five different iodinated contrast media and physiologic saline into the bladders of subjects.
    • Assessment of tolerated volumes for each agent.
    • Histopathological examination of bladder mucosa at various time points (6 hours to 3 months) to identify changes.

    Main Results:

    • Significantly greater volumes of saline were tolerated compared to all tested iodinated contrast media.
    • Dimer X was tolerated in the smallest volume among the contrast media.
    • Saline caused transient dehydration changes in the bladder mucosa, resolving within 24 hours.
    • Iodinated contrast media induced persistent dehydration, hydropic, and desquamative changes in the bladder mucosa for up to 3 months.
    • No significant difference in the severity of mucosal changes was observed among the different contrast media.
    • No inflammatory changes were noted with any agent.

    Conclusions:

    • Physiologic saline is better tolerated in terms of volume than iodinated contrast media for bladder instillation.
    • Iodinated contrast media cause prolonged histological alterations to the bladder mucosa.
    • The specific reasons for the differential volume tolerance remain undetermined.

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