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Related Concept Videos

Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Cellular Differentiation00:57

Cellular Differentiation

How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
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An Enzyme- and Serum-free Neural Stem Cell Culture Model for EMT Investigation Suited for Drug Discovery
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Published on: August 23, 2016

Cellular transitions and tissue engineering.

Aaron Schindeler1, Mille Kolind, David G Little

  • 1Department of Orthopaedic Research & Biotechnology, the Children's Hospital at Westmead, Sydney, Australia. Aaron.Schindeler@sydney.edu.au

Cellular Reprogramming
|April 5, 2013
PubMed
Summary
This summary is machine-generated.

Epithelial-to-mesenchymal transition (EMT) and endothelial-to-mesenchymal transition (EndMT) are key cellular processes in development and disease. Understanding EMT and EndMT may reveal new regenerative medicine strategies for tissue repair and fibrosis reduction.

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Area of Science:

  • Cell Biology
  • Developmental Biology
  • Regenerative Medicine

Background:

  • Epithelial-to-mesenchymal transition (EMT) and endothelial-to-mesenchymal transition (EndMT) involve significant changes in cell characteristics.
  • These transitions are crucial for embryonic development but can be pathologically altered in diseases, including fibrosis.
  • While EMT is known in processes like gastrulation and cardiogenesis, EndMT's role is increasingly recognized in tissue fibrosis and musculoskeletal pathology.

Purpose of the Study:

  • To review the roles of EMT and EndMT in biological processes.
  • To explore the potential impact of EMT and EndMT on tissue engineering and regenerative medicine.
  • To identify how these cellular transitions might offer new approaches for fibrosis management and progenitor cell identification.

Main Methods:

  • Literature review of studies on EMT and EndMT.
  • Analysis of the involvement of EMT and EndMT in embryonic development and disease.
  • Discussion of the implications of EMT and EndMT for tissue repair and fibrosis.

Main Results:

  • EMT and EndMT are fundamental cellular transitions with roles in development and disease.
  • These processes are implicated in fibrosis and musculoskeletal pathology.
  • EMT and EndMT offer potential avenues for therapeutic strategies in regenerative medicine.

Conclusions:

  • EMT and EndMT are critical cellular mechanisms with implications beyond development.
  • Further research into EMT and EndMT could lead to novel treatments for fibrotic diseases.
  • Harnessing EMT and EndMT may enhance progenitor cell therapies for tissue regeneration.