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General synthetic approach to functionalized dihydrooxepines

K C Nicolaou1, Ruocheng Yu, Lei Shi

  • 1Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States. kcn@scripps.edu

Organic Letters
|April 5, 2013
PubMed
Summary

A new three-step method creates functionalized 4,5-dihydrooxepines from cyclohexenones. This process utilizes a regioselective Baeyer-Villiger oxidation and enol phosphate intermediates for efficient synthesis.

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