Related Experiment Video
Updated: May 12, 2026

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
Published on: March 14, 2019
Sequence type 398 meticillin-resistant Staphylococcus aureus infection in a pet rabbit
1Department of Pathobiology, Institute for Bacteriology, Mycology and Hygiene, University of Veterinary Medicine, Vienna, Austria. igor.loncaric@vetmeduni.ac.at
Background:
Meticillin-resistant Staphylococcus aureus (MRSA) is a frequent pathogen of humans and many animal species, and has become established as a veterinary pathogen.
Case Report:
In this case report we describe an MRSA infection in a dwarf rabbit, treatment of the infection and, subsequently, the genetic analysis of the isolated strain. The pet rabbit was presented to an animal hospital due to recurrent swellings on the head and on the neck. Bacteriological examination yielded Staphylococcus aureus, which was resistant to β-lactam antibiotics. The isolate was confirmed as an MRSA by mecA PCR, Panton-Valentine leukocidin (PVL) negative, and typed as multilocus sequence type (ST)398/staphylococcal protein A (spa) type t011/staphylococcal cassette chromosome mec (SCCmec) type SCCmecIVa. The rabbit was treated with rifampicin for 2 weeks. After 2.5 weeks the rabbit was clinically normal and control swabs were negative for MRSA.
Conclusions And Clinical Importance:
This study is the first to report MRSA in a rabbit in Austria. This study contributes to the growing evidence that MRSA ST398 could be isolated from a variety of animals.
Insights
Meticillin-resistant Staphylococcus aureus (MRSA) was identified in a dwarf rabbit in Austria. Treatment with rifampicin successfully resolved the infection, highlighting MRSA ST398
Area of Science:
- Veterinary Medicine
- Microbiology
- Infectious Diseases
Background:
- Meticillin-resistant Staphylococcus aureus (MRSA) is a significant pathogen in both human and animal health.
- MRSA has increasingly been recognized as a veterinary pathogen, posing risks in various animal species.
Observation:
- A dwarf rabbit presented with recurrent swellings on its head and neck.
- Bacteriological examination confirmed Staphylococcus aureus resistant to beta-lactam antibiotics.
Findings:
- The isolate was identified as MRSA, confirmed by mecA PCR, and found to be Panton-Valentine leukocidin (PVL) negative.
- Genetic analysis revealed the MRSA strain as multilocus sequence type (ST)398, spa type t011, and SCCmec type IVa.
- The rabbit was successfully treated with rifampicin over two weeks, with subsequent negative MRSA swabs.
Implications:
- This case represents the first report of MRSA in a rabbit in Austria.
- The findings contribute to the understanding of MRSA ST398's prevalence and adaptability across diverse animal hosts.
- This underscores the importance of surveillance and appropriate treatment strategies for MRSA in companion animals.
Related Concept Videos
Clinical Significance of Antibiotic Resistance
Staphylococcal Skin Infections
Mechanism of Antibiotic Resistance in MRSA

