Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Principle component analysis and hierarchical clustering of body morphometric measurements along with the milk composition analysis of AzaKheli buffaloes: a neglected livestock genetic resource of Pakistan.

Tropical animal health and production·2026

Same author

Exfoliating microplastics intensifies heavy metal uptake and physiological stress in wastewater-irrigated chili plants.

International journal of phytoremediation·2026

Same author

Signature-aware deep learning reveals distinct driver gene programs and mutational processes in glioblastoma and colon adenocarcinoma.

Computational biology and chemistry·2026

Same author

Distinct mutational landscapes and phylogenomic insights of the SARS-CoV-2 delta variant in Pakistan and India: Regional evolution, novel mutations, and epidemiological implications.

PloS one·2026

Same author

Sodium benzoate induces reproductive toxicity via hormonal disruption, ovarian damage and altering kisspeptin/RFRP-3 expression.

Regulatory toxicology and pharmacology : RTP·2026

Same author

Optimizing biochar via microwave irradiation for phyto-stabilization of heavy metals through chili plants: a novel approach for sustainable bioremediation.

International journal of phytoremediation·2026

Search research articles

Related Experiment Video

Updated: May 12, 2026

Multiplex Immunohistochemistry Staining for Paraffin-embedded Lung Cancer Tissue

Multiplex Immunohistochemistry Staining for Paraffin-embedded Lung Cancer Tissue

Published on: November 21, 2023

Carcinoma multiplex.

Syed Aslam Shah¹, Umbreen Riaz, Imran Zahoor

¹Department of General Surgery, Pakistan Institute of Medical Sciences, Islamabad. drsaslamshah@gmail.com

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

|April 5, 2013

Summary

This summary is machine-generated.

This case report details a rare instance of a patient developing both parotid gland mucoepidermoid carcinoma and colon adenocarcinoma. These distinct cancers in unrelated organs highlight the complexity of multiple primary malignancies.

More Related Videos

Multiplex Cyclic Fluorescent Immunohistochemistry

Multiplex Cyclic Fluorescent Immunohistochemistry

Published on: January 26, 2024

Automated Multiplex Immunofluorescence Panel for Immuno-oncology Studies on Formalin-fixed Carcinoma Tissue Specimens

Automated Multiplex Immunofluorescence Panel for Immuno-oncology Studies on Formalin-fixed Carcinoma Tissue Specimens

Published on: January 21, 2019

Related Experiment Videos

Last Updated: May 12, 2026

Multiplex Immunohistochemistry Staining for Paraffin-embedded Lung Cancer Tissue

Multiplex Immunohistochemistry Staining for Paraffin-embedded Lung Cancer Tissue

Published on: November 21, 2023

Multiplex Cyclic Fluorescent Immunohistochemistry

Multiplex Cyclic Fluorescent Immunohistochemistry

Published on: January 26, 2024

Automated Multiplex Immunofluorescence Panel for Immuno-oncology Studies on Formalin-fixed Carcinoma Tissue Specimens

Automated Multiplex Immunofluorescence Panel for Immuno-oncology Studies on Formalin-fixed Carcinoma Tissue Specimens

Published on: January 21, 2019

Area of Science:

Oncology
Pathology

Background:

Multiple primary cancers in a single patient are uncommon but documented.
Synchronous or metachronous malignancies in unrelated, non-paired organs are exceptionally rare.

Observation:

A 55-year-old male presented with parotid gland mucoepidermoid carcinoma, followed by pseudomyxoma peritonei later diagnosed as colon adenocarcinoma.
The patient experienced a recurrence of parotid mucoepidermoid carcinoma, successfully treated with surgery and myocutaneous flap reconstruction.

Findings:

Immunohistochemistry was utilized to investigate the potential clonal origin of the parotid and colon malignancies.
The findings suggest distinct monoclonal etiologies for the two primary tumors, supporting separate origins.

Implications:

This case represents the first reported instance of carcinoma multiplex involving the colon and parotid gland.
The findings underscore the importance of thorough investigation in patients with multiple primary cancers, even in unusual combinations.